The Memorial Hospital IVF and Reproductive Genetics Centre has achieved many “firsts” in Turkey:

INTRA CYTOPLASMIC SPERM INJECTION (ICSI)

ICSI, also known as “microinjection”, is the injection of sperm into the ovum of the female. It was first carried out in Turkey by our team in September 1994.

Turkey’s first microinjection baby was delivered by our team in July 1995.

MICRO EPIDIDYMAL SPERM ASPIRATION (MESA)

MESA is a procedure for obtaining sperms   from  the epididymis using an operating microscope . It was first carried out by our team in Turkey on 16th January. 1995.

The first live birth in Turkey after a pregnancy achieved by MESA was the delivery of twins at our centre on 22nd September. 1995.

TESTICULAR SPERM EXTRACTION (TESE)

TESE, a  procedure for obtaining sperms from testis tissue by an open testicular operation  was first carried out  in Turkey by our team on 17th January. 1995.

The first “TESE baby”in Turkey  was delivered by our team in October 1995.

TESTICULAR SPERM ASPIRATION (TESA)

TESA, a procedure for obtaining sperms from testis tissue by aspiration with a syringe. was first performed  in Turkey by our team in 1995.

The first “TESA baby” in Turkey was delivered by our team on 27th September.1995.

PERCUTANEOUS EPIDIDYMAL SPERM ASPIRATION (PESA) 

PESA, a procedure for obtaining sperms from epididymis tissue by aspiriation with a syringewas first performed  in Turkey by our team in  1995.

The first “ PESA  baby”in Turkey was delivered by our team on  in 1995.

 

Using of testicular spermatid cells for the first time. First live birth after a pregnancy achieved by using spermatid cells in 1995. Using of total immotile sperms for the first time and live birth in 1995.

EMBRYO FREEZING

Embryo Freezing is a procedure for storing good  quality embryos when they exceed the number required for transfer.It  was first performed in Turkey by our team on 31st July 1996.

The first babies (twins) resulting from frozen embryos were delivered by our team in 1997.

DEVELOPING OF A BLASTOCYSTE FOR THE FIRST TIME

Live birth in 1997

BLASTOMERE BIOPSY AND PRE-IMPLANTATION GENETIC DIAGNOSIS

The first live birth in Turkey  after blastomer biopsy and pre-implantation genetic diagnosis was achieved by our team in 1997.

POLAR BODY BIOPSY

The first polar body biopsy in Turkey was performed by our team in 2000.

BLASTOCYST STAGE EMBRYO FREEZING

In 1998, our team was the first in Turkey to achieve a birth throughblastocyst stage embryo freezing.

ENDOMETRIAL CO-CULTURE

The first pregnancy and live birth in Turkey using this technique was achieved by our team in 2004. 

  

SINGLE OOCYTE FROM NATURAL MENSTRUAL CYCLE WITH ICSI

The first pregnancy and live birth in Turkey using this technique was achieved by our team in 1999.

OVARIAN TISSUE FREEZING

This procedure  was first performed in Turkey by our team in 2001.

Memorial Hospital IVF and Reproductive Genetics Centre

First Preimplantion Genetic Diagnosis of Single Gene Disorders and HLA Typing

First case of PGD for single gene disorders and HLA typing in Turkey was performed in our center in 2001. Hematopoietic stem cell transplantation was performed successfully from 44 children who were conceived by preimplantation genetic diagnosis performed in Memorial Hospital. Transplantations were performed by successful pediatric hematologists from respectable university hospitals of Turkey. By the help of this technique affected children are cured by the help of their siblings conceived by PGD method. 

Conditions that are cured for the first time in the world with preimplantaion genetic diagnosis and HLA typing performed in our center

World’s first successful case of preimplantation HLA typing for Acute Myeloid Leukemia (AML) was performed in our center in 2008. After successful bone marrow transplantation performed in İstanbul, the affected child was completely cured and no complications were observed in both children.

Solak Family: Sinem (affected by AML) and her HLA match sister conceived by preimplation HLA typing.	2 years after transplantation

• World’s first case of successful Preimplantation HLA Typing for Acute Lymphoblastic Leukemia (ALL):  

      For the first time in the world, a 5 year old child suffering from ALL was cured by bone marrow transplantation from his sibling conceived by preimplantation HLA typing performed in our center in 2012.

• World’s first case of Preimplantation Genetic Diagnosis and HLA typing for Glanzmann's thrombasthenia: 

       2 healthy and %100 HLA match twins were conceived with PGD for  Glanzmann's thrombasthenia in our center in 2008. The cord blood obtained from the twins was used in the transplant performed in Italy in 2009. The affected sibling was completely cured and no complications were observed. 

Healthy twins who are HLA match with their sister who was suffering from Glanzmann's thrombasthenia		Twins and their sister after transplantation

• PGD was performed for Lafora disease in our center in 2011. After PGD, frozen embryos were transferred and a healthy child was born for the first time in the world for Lafora disease with use of PGD. 
• First case of PGD for Bartter syndrome was performed in our center. 3 healthy embryos were obtained from 13 embryos evaluated and a healthy child was born after the transfer. 

Conditions that are cured for the first time in Turkey with preimplantaion genetic diagnosis and HLA typing performed in our center

• PGD for Beta thalassemia was performed for the first time in Turkey in 2001 in our center and HLA match and healthy baby was conceived by PGD for the first time. 
• Cord blood transplantation was performed for the first time from twins conceived by PGD to their affected sibling (beta thalassemia) in 2004 in Italy. Complete cure was achieved without any complications.

Sina (affected by thalassemia) with his mother (during pregnancy to twins)	Healthy and HLA match twins
Sina who has recovered after cord blood transplant

33 thalassemia patients were cured by hematopoietic stem cell transplantation after PGD and HLA typing done successfully in memorial hospital 

PGD was performed for the first time in Turkey for Wiskott Aldrich Syndrome (WAS) in 2003 and healthy HLA match embryos were found. The affected sibling was cured by transplantation performed in Israel using the cord blood and bone marrow from his sister conceived by PGD. 3 children suffering from WAS cured by stem cell transplantation using PGD method in our center.

HLA match baby joins Mut Family…	Cured child (left) using cord blood from his sister (middle) and their healthy brother (right)

• PGD was performed for the first time in Turkey for Diamond Blackfan Anemia (DBA). HLA match and healthy embryos were transferred and after delivery of the baby, sick sibling was cured by bone marrow transplantation in 2008. 

Brother suffering from Diamond Blackfan Anemia was cured by bone marrow and cord blood transplantation performed in 2008 in Italy.

• PGD was performed for the first time in Turkey for X-Adrenoleukodystrophy (X-ALD). HLA match and healthy embryos were transferred and after delivery of the baby, sick sibling was cured by bone marrow transplantation in 2008. 

Kethuda family had 2 children affected by X-Adrenoleukodystrophy (X-ALD). Older affected brother was cured by bone marrow transplant obtained from the HLA match sibling born after PGD performed in Istanbul Memorial Hospital. The transplant was successfully performed in Istanbul Capa Medical Faculty. Younger affected sibling was cured by cord blood transplant found from a foreign institution.

• First successful case of PGD for Fanconi Anemia in Turkey was performed in Memorial Hospital. The transplant was performed successfully in 2011. 

Children of Yılmaz Family… Affected brother was cured by transplantation from his bother performed in 2011

 

• PGD was performed successfully for the first time in Turkey for Sickle Cell Anemia (SCA) in our center. Bone marrow transplant was achieved in 2011 with success. 

Nazlı who was born in 2009 after PGD, helped to cure her sister suffering from sickle cell anemia in 2011 with bone marrow transplantation...

Other first cases of PGD in Turkey with healthy live birth:

• Familial Hemophagocytic lymphohistiocytosis in 2011.
• Charcot-Marie-Tooth in 2010 
• Congenital deafness (Connexin 26) in 2008
• Facioscapulohumeral muscular dystrophy (FSHD) in 2007
• Fragile X in 2008
• Galactosemia in 2009
• Hereditary multiple exostoses in 2011
• Glucose-6-phosphate dehydrogenase (G6PD) deficiency in 2008
• Huntington Disease in 2005
• Myotonic Dystrophy in 2007
• Cystic Fibrosis in 2006
• Leber's congenital amaurosis in 2011
• Mucopolysaccharidosis Type VI in 2009
• Mucolipidosis Type I in 2011 
• Niemann Pick in 2007 (single healthy birth) and 2010  (twin birth for the same family) 
• Neurofibromatosis in 2006
• Osteogenesis in imperfecta in 2010
• Osteopetrosis in 2011.
• Propionic  in 2010
• Spinal Muscular Atrophy (SMA) in 2004
• Mucopolysaccharidosis Type IIIB (Sanfillippo syndrome) in 2004.
• Spastic Paraplegia in 2005 
• Tay Sachs in 2011
• Tuberous sclerosis in 2005

Family members who had a healthy child with PGD for Galactosemia

 

Healthy girl after PGD for Glucose-6-phosphate dehydrogenase (G6PD) deficiency

 

Healthy twins after PGD for mucolipidosis Mukolipidozis için yapılan PGT işlemi ardından doğan sağlıklı ikizler…

 

Eren who was born after PGD for Neurofibromatosis in 2007 and his parents

 

Hena was born after PGD for Osteogenesis imperfect in 2011

 

Buyukbay family with their healthy  twins born after PGD for Sanfilippo disease

 

Healthy twins of Aktaş family after PGD for Tay Sachs disease