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17th Preimplantation Genetic Diagnosis (PGD) Congress

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Prof. Kahraman stated in her talk that female age is the most significant predictor of the rate of chromosomally normal embryos (euploidy) and that the euploidy rate does not directly correlate with the number of oocytes retrieved at pick-up.

The Preimplantation Genetic Diagnosis International Society (PGDIS) organized the 17th Preimplantation Genetic Diagnosis (PGD) conference on 3-6 May in Bangkok, Thailand. Prof. Dr. Semra Kahraman, Head of the IVF Center at Memorial Şişli Hospital, and who has served the PGDIS Executive Committee as the past-president and as a founding member, delivered a talk entitled "PGD in low, normal and high responders" as an invited speaker at the session entitled "Reproductive outcome of PGD". Professor Kahraman has also participated in the PGDIS board meeting and was the chair of the session entitled "Mosaicism and sub-chromosomal variations". The quality control manager of the IVF Laboratory, Caroline Pirkevi PhD, the head of the reproductive genetics center Dr. Murat Çetinkaya, MD, PhD and molecular biologist Mehmet Ali Tüfekçi, PhD, have participated to the congress with three oral presentations.

Prof. Dr. Semra Kahraman


Prof. Semra Kahraman MD.

Prof. Kahraman stated in her talk that female age is the most significant predictor of the rate of chromosomally normal embryos (euploidy) and that the euploidy rate does not directly correlate with the number of oocytes retrieved at pick-up. Also, the probability of finding at least one euploid embryo (POE) decreases significantly with advancing maternal age. Anti-Mullerian Hormone (AMH), day-3 Follicle Stimulating Hormone (FSH), the number of retrieved and of mature oocytes and the number of top and good quality and biopsied blastocysts are the main variables affecting POE after adjustment for age, indicating that ovarian reserve and response have a significant impact. In conclusion, Prof. Kahraman reported that the live birth rates correlate significantly with maternal age and the number of biopsied embryos. PGD has a high success rate in terms of live births for patients between the ages of 35 and 42. These findings emphasize the importance of evaluating and counselling the patients for factors both negative and positive, which may affect the success of PGD.

Memorial Şişli Hospital IVF and Reproductive Genetics Center was represented by three oral presentations at the conference. Dr. Murat Çetinkaya, MD, PhD presented his abstract entitled "Simultaneous detection of chromosomal aneuploidy and a monogenic disease by next-generation sequencing with linkage analysis". Mehmet Ali Tüfekçi, PhD presented his abstract on "Mitochondrial DNA content is not related with pregnancy but with euploidy". Caroline Pirkevi, PhD presented the abstract entitled "The impact of a morphokinetic selection on the outcome of euploid embryos".
 

Dr. Murat Çetinkaya, PhD

Mehmet Ali Tüfekçi, PhD

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